2021715 · AST-3424/OBI-3424 (denoted by 3424) is a novel prodrug bis-alkylating agent activated by AKR1C3. AKR1C3 is overexpressed in many types of cancer, particularly in liver, non-small cell lung, gastric, renal and CRPC cancer. Currently 3424 is being studied in phase 1/2 clinical trials for the treatment
202077 · ISO 24034:2020 - This document specifies requirements for the classification of solid wire electrodes, solid wires and rods for fusion welding of titanium and titanium alloys. The classification is based on their chemical composition. The compositions of solid wire electrodes for metal inert gas (MIG) welding are the same as solid wire
OBI-3424 is a first-in-class novel prodrug that can selectively act on a variety of cancers with overexpression of Aldo-keto reductase family 1 member C3 (AKR1C3). OBI-3424 has been granted Orphan Drug Designation (ODD) for the treatment of hepatocellular carcinoma (HCC) and acute lymphocytic leukemia (ALL). The Phase I/II dose escalation study ...
Turn on fluorescent detection of biogenic amines in
1 · Inspired by above strategies, based on R6G-loaded and MnO 2 nanosheets coated-MSNs ([email protected] 2), we developed a simple turn-on fluorescence probe for the sensitive detection of BAs (Scheme 1).MSNs were first synthesized by a sol-gel growth method and then modified with R6G to obtain [email protected] (λ emi: 553 nm).MnO 2
Graphene for Antimicrobial and Coating Application
Graphene is a versatile compound with several outstanding properties, providing a combination of impressive surface area, high strength, thermal and electrical properties, with a wide array of functionalization possibilities. This review aims to present an introduction of graphene and presents a comprehensive up-to-date review of graphene as an
Direct measurement of the critical power of femtosecond
Abstract. We report a simple experiment to directly determine the critical power for self-focusing in air by measuring the focal shift of the focused femtosecond Ti:sapphire laser pulses. The measured critical power is 10 GW for the 42 fs laser pulse; it gradually decreases to 5 GW for (chirped) pulse duration longer than 200 fs.
Transformers are compatible with TI Fly-Buck converters.
20191220 · For example, the TI LM5017 demo board utilizing a Premier Magnetics TSD-3425 transformer has a demonstrated efficiency of greater than 90%. Expanding Premier's popular TSD Series, the models in the Fly-Buck series are offered to support three popular Fly-Buck circuit configurations. ... The Model TSD-3424, in an EP13 package,